- Country: France
- Summary: Purchase of Service: Synthesis and Qualification of Long Non-Coding Mrna Sequences Interacting with P53
- FRT Ref No: 128367862
- Deadline: 23 Oct 2025
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: MAPA-Synthesis-mRNA-p53
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- Description:
- The desired service The maternally expressed gene 3 (MEG3) encodes a lncRNA (long non-coding RNA) with a tumor suppressor effect which modulates the responses of the p53 protein. complementarity of bases to form mutually exclusive pseudoknot structures (see figure). have been shown to impair MEG3-dependent stimulation of p53 in vivo and disrupt MEG3 folding in vitro [1].The service required consists of the production of synthetic lncRNA sequences in biologically active conformations that recapitulate MEG3 pseudoknot structures in a chemical form allowing their encapsulation into controllable liposomal carriers for delivery into organoids cancer cells and murine xenografts. negative control.The production protocol will integrate non-denaturing purification of lncRNAs with hydrodynamic analysis in solution and a atomic force microscopy (AFM) imaging to produce highly homogeneous lncRNA preparations, controlled by visualization of their 3D topology at ~15 A resolution [2].
- Documents:
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CLICK HERE TO LOGINPurchase of Service: Synthesis and Qualification of Long Non-Coding Mrna Sequences Interacting with P53 - France Tender
The INSERM - LYON REGIONAL DELEGATION, a Government sector organization in France, has announced a new tender for Purchase of Service: Synthesis and Qualification of Long Non-Coding Mrna Sequences Interacting with P53. This tender is published on FranceTenders under FRT Ref No: 128367862 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-10-23.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
